10/27/05 NEWSLETTER carlstonmd.com
Dear Patients HOME

This newsletter is one of those simplistic but fundamental commentaries. Simplistic, as there is only one item. Fundamental, because the thought process is vital and widely applicable. I think it will help you understand my comments on many specific topics by acquainting you with the habit of thought that leads me forward.

Best, Michael Carlston, M.D.
www.carlstonmd.com 
707-545-1554

In This Issue: INDEX
  • MODERATION AND FINDING YOUR WAY IN THE DARK
  • MODERATION AND FINDING YOUR WAY IN THE DARK TOP

    Many of the health-related complex issues arising recently contain the same central confusion, which is the need to make decisions without full knowledge. That is what health care providers do all day every day.

    On the one hand, this can be extremely frustrating. After all, who really likes guessing, no matter how educated that guess may be? We all want consistent, reliable results. On the other, life and living organisms are innately only semi-predictable. We seldom know enough to know the full consequences of our actions.

    As I have to deal with this uncertainty continually, it has taught me a good approach to making tough decisions. This applies to everything from using vitamins and drinking lots of water, to even some health-related political choices. When semi-informed decisions are required, I find that following this process leads to pretty good choices. The process seems to be innately moderating, as giving undue importance to small sprigs of data or wild speculation, can lead you far out onto a thin limb leaving you in a tenuous position.

    First, I gather information about what is known. One example is that we know that increased levels of many vitamins are associated with lowered rates of certain diseases, but supplementation with those very same vitamins is sometimes associated with increased risk of the disease.

    Another example is that we know that genetically modified foods by definition contain amino acids/proteins from other living organisms, and that modification fundamentally alters the biological activity of the organism in the environment (allergenicity, toxicity, ability to spread, etc., etc.) Although we do know about the horrendous problem with eosinophilic myalgia that resulted from genetically modified L-trypotophan, we have not had significant reports of ill health effects from GMO foods.

    To support your own information gathering, one of the best sources of information on the interface between foods, industry and politics is Marion Nestle, Ph.D. I highly recommend her books SAFE FOOD: Bacteria, Biotechnology and Bioterrorism and FOOD POLITICS: How the Food Industry Influences Nutrition and Health. Although she is a high-powered academic, her books are interesting and clearly written.

    Next comes critically analyzing that information to sort out the deeper meanings, the clues about what that information is really telling us. In the case of vitamins, synthetic vitamins are different than natural forms taken along with other nutrients. In many instances we know that wild foods contain much, much higher levels of vitamins and minerals than domesticated ones (a notable exception is Vitamin E.) So, we need to consider the forms of the vitamin, attend to a balanced overall diet and continue to learn about varying individual needs.

    In the case of GMO foods, the same issue of incomplete study of the problem looms large. In other words, an inadequate research base prevents full understanding of the problem. If you have yet to look carefully for a snake in the grass, you won’t know it is there until it bites you. Other factors do come into play when industrial technology is involved. In my years in medicine I have seen many, many strongly advocated, safe treatments turn out to be ineffective or dangerous. That makes me skeptical of the latest advances, particularly when those corporations or physicians with something to gain tout them. In the case of genetically modified organisms, the economic stakes are quite high.

    Finally, we move on to consider the repercussions, the consequences of action and inaction. In medicine we call this the risk/benefit ratio. If the intervention is not likely to cause harm, the need for convincing proof of efficacy is entirely different than it would be for a high risk procedure. For vitamins, it becomes an individual matter. A patient with heart disease who has never taken vitamin E is at much greater risk than another person taking high doses of B vitamins.

    GMOs are potentially extremely risky. They could be beneficial as well, but in my opinion, considering the uncertain scientific data and the potential for extreme and entirely unforeseen consequences, the risk is too great at this time.
    The GMO issue is a good example of another aspect of this decision-making process. There are situations in which the penalty for inaction is so much less than the risks of a rash decision. The wisest decision is to place things on hold until more is known. Many patients follow this approach with certain immunizations. The official medical recommendation is to vaccinate children for some diseases that would only cause harm in adulthood because we have the kids in our offices already. Medical authorities feel we can’t trust those patients to come back later. Because we learn more with time, wise families will instead chose to hold off, recognizing their right to delay as well as their responsibility to keep informed in coming years.

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